| Thursday,Sept 6, 2018 | | |
| Atlanta at Philadelphia | 8:20 PM | NBC |
| | |
| Sunday, Sep 9, 2018 | | |
| Buffalo at Baltimore | 1:00 PM | CBS |
| Cincinnati at Indianapolis | 1:00 PM | CBS |
| Houston at New England | 1:00 PM | CBS |
| Jacksonville at N.Y. Giants | 1:00 PM | FOX |
| Pittsburgh at Cleveland | 1:00 PM | CBS |
| San Francisco at Minnesota | 1:00 PM | FOX |
| Tampa Bay at New Orleans | 1:00 PM | FOX |
| Tennessee at Miami | 1:00 PM | FOX |
| Kansas City at L.A. Chargers | 4:05 PM | CBS |
| Dallas at Carolina | 4:25 PM | FOX |
| Seattle at Denver | 4:25 PM | FOX |
| Washington at Arizona | 4:25 PM | FOX |
| Chicago at Green Bay | 8:20 PM | NBC |
| | |
| Monday, Sep 10, 2018 | | |
| N.Y. Jets at Detroit | 7:10 PM | ESPN |
| L.A. Rams at Oakland | 10:20 PM | ESPN |
